Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond
نویسندگان
چکیده
منابع مشابه
Transcription of inflammatory genes: long noncoding RNA and beyond.
The innate immune system must coordinate elaborate signaling pathways to turn on expression of hundreds of genes to provide protection against pathogens and resolve acute inflammation. Multiple genes within distinct functional categories are coordinately and temporally regulated by transcriptional on and off switches in response to distinct external stimuli. Three classes of transcription facto...
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Recent analyses based on high-throughput transcriptome data have revealed that the fraction of the genome that is transcribed largely exceeds the fraction encoding protein. Transcription of unconventional genes into noncoding RNAs is widespread and, in mammals, these RNAs comprise at least half the total number of RNAs transcribed by RNA polymerase II. Although the function of the majority of n...
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Investigation of noncoding RNAs is in rapid progress, especially regarding translational repression by small (short) noncoding RNAs like microRNAs with 20-25 nucleotide-lengths, while long noncoding RNAs with nucleotide length of more than two hundred are also emerging. Indeed, our analysis has revealed that a long noncoding RNA transcribed from cyclin D1 promoter of 200 and 300 nucleotides exe...
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ژورنال
عنوان ژورنال: Journal of Interferon & Cytokine Research
سال: 2015
ISSN: 1079-9907,1557-7465
DOI: 10.1089/jir.2014.0120